Situated only 8 minutes on foot from the Church of Saint Pio of Pietrelcina, the 3-star smoke-free Hotel San Francesco San Giovanni Rotondo offers air-conditioned rooms with Wi-Fi in public areas. Featuring a shopping area and a restaurant, this San Giovanni Rotondo hotel is 3.5 km from the Sanctuary of Saint Matthew on Gargano.

The centre of San Giovanni Rotondo can be reached in 25 minutes' walk of the hotel, and such cultural venues as the Dinosaur Paleontological Museum are nearly a 10-minute ride away. Located merely 500 metres from the Monumental Via Crucis, the San Francesco is 2.2 km from the historic center of San Giovanni Rotondo. The accommodation is situated in the vicinity of the Padre Pio Wax Museum, while Convento bus station lies just 0.7 km away. Aeroporto di Foggia "Gino Lisa" airport can be found 55 km from this San Giovanni Rotondo hotel.

Overlooking the mountain, the 20 rooms are appointed with climate control, as well as modern facilities such as complimentary wireless internet and a flat-screen TV with satellite channels. Providing a bidet, a separate toilet, and a shower, the bathrooms also have hairdryers and a shower cap.

A buffet breakfast is available each morning at the San Francesco San Giovanni Rotondo. An à la carte restaurant at the property serves Mediterranean specialities. This hotel invites guests to the lounge bar to relax with a drink and enjoy city views. The bar area includes a lounge. Hotel San Francesco is approximately 5 minutes on foot from La Piccola Baita restaurant with its Mediterranean dishes.