Featuring a shared lounge and a private swimming pool, the smoke-free Palazzo Guglielmo Hotel Vignacastrisi lies 3.8 km from Porto Miggiano Beach. Boasting access to the Grotta Zinzulusa cave, about 25 minutes' walk away, this 4-star hotel includes a sun deck, spa therapy, and a patio providing guests with spacious rooms.

The comfortable hotel is located in the southern part of Vignacastrisi, near hot springs. The Palazzo Guglielmo is in close proximity to the Church of Mary Most Holy Immaculate and 20 minutes' drive from Santa Maria di Leuca. Guests might as well visit Canali Creativi, which is 1.5 km away. This accommodation stands in the vicinity of the Mother Church, popular with pilgrims and tourists alike. The hotel is located near a boat dock.

Furnished with a writing table, the 16 rooms also include such conveniences as wireless internet, along with a mini fridge bar. There are double bedrooms and family bathrooms with a bidet, a separate toilet, and a shower provided. Bathrooms inlude a bidet, a separate toilet, and a shower, and such fine comforts as hairdryers and towels. Guests can enjoy views of the garden from Palazzo Guglielmo Hotel.

A fine Italian breakfast is available in the restaurant. There is a lounge bar onsite. The bar area includes a terrace. La Casa Dell'Angelo is located next to the Palazzo Guglielmo Vignacastrisi and serves Italian dishes, approximately 100 metres away.