Featuring car, moped, and scooter rentals, as well as Wi-Fi in public areas, the 4-star Palazzo Guglielmo Hotel Vignacastrisi is around a 25-minute walk from the Grotta Zinzulusa cave. The hotel is 2.7 km from the Cala dell'Acquaviva and provides guests with a solarium, a steam room, and a hot tub.

This family hotel is located in the southern part of Vignacastrisi, near hot springs. Poggiardo is 10 minutes' drive from Palazzo Guglielmo Hotel, while the Church of Mary Most Holy Immaculate is nearly 5 minutes' walk away. Also, Canali Creativi is situated 1.5 km away. This accommodation stands in the vicinity of the Mother Church, popular with pilgrims and tourists alike. Due to a location near a boat dock, the hotel gives quick access to other parts of Vignacastrisi.

For your comfort, you will find air conditioning along with a mini fridge bar in each of the 16 rooms. Most rooms of the Palazzo Guglielmo feature a furnished balcony. Bathrooms with a bidet, a separate toilet, and a shower, also include toiletries and towels. Guests can take advantage of views of the garden.

This property offers a fine Italian breakfast in the restaurant. For an enjoyable stay, the Palazzo Guglielmo Vignacastrisi offers the à la carte restaurant serving Italian dishes. To cater to every palate, it offers a vegan menu. Guests can unwind at the on-site lounge bar with a favourite drink. The bar area includes a terrace. La Corte degli Ulivi offers a wide range of Apulian dishes and lies approximately 300 metres away.