Situated just 1.5 km from the Railway Museum of Puglia and 16 minutes' walk from the University museum "MUSA - Museo Storico-Archeologico dell'Universita del Salento", the smoke-free Palazzo Bernardini Suites Lecce hotel features a private art gallery. A wine bar as well as a sunbathing terrace, spa therapy, and a patio can be enjoyed at this 4-star bed & breakfast, boasting the setting just near the Historic Center.

The hotel is centrally located within 5 minutes' walk of the Sant'Oronzo Square, right in the historical centre of Lecce. The Parco di Belloluogo is 1.6 km from the Palazzo Bernardini Suites, and Casale airport is 50 km away. This accommodation is immersed in local restaurants, a wine bar, and cafes that you can visit during your stay. The hotel stands in close proximity to the Baroque church "Basilica of Santa Croce", popular with pilgrims and tourists alike. Palazzo Bernardini Suites hotel is near a train station and Camera di Commercio/Stazione bus stop is about a 5-minute walk away.

The rooms comprise a balcony and a dining area complete with an iron with ironing board and air conditioning, as well as a flat-screen TV with satellite channels. They are appointed with a writing table, and also feature coffee/tea making equipment. The bathrooms come with a bidet, a walk-in shower, and a separate toilet, along with a hairdryer and bath sheets. Guests can enjoy views of the garden from the Palazzo Bernardini Suites Lecce.

A continental breakfast, with different food options, is offered each morning. Mediterranean cuisine is served at Vico dei Sotterranei that lies approximately 100 metres away.