The smoke-free Hotel Kyrie Isole Tremiti San Domino is situated in the very heart of San Domino approximately a 10-minute walk from Cala delle Arene Beach. This 4-star hotel lies within a few blocks of the Cave of the Violets, and offers an à la carte restaurant and an outdoor swimming pool onsite.

The hotel is 500 metres from Adriatic Sea in San Domino. Vieste is 50 minutes' drive from Hotel Kyrie Isole Tremiti, while the Tremiti Archipelago is a mere 15 minutes' walk away. Nature lovers will appreciate the vicinity of Cala dei Benedettini, which is metres away. Spido Cove, as well as the Small Cala Matano Sandy Beach, are located a stone's throw from the property.

Comprising a balcony and a terrace, the soundproofed rooms welcome guests with an air conditioner, and offer a flat-screen TV with satellite channels. Appointed with a carpeted floor, the rooms also come with a minibar. A bidet, a separate toilet, and a shower along with such comforts as hairdryers and bath sheets are featured in the bathrooms.

The restaurant at the Kyrie Isole Tremiti San Domino serves Italian cuisine. This San Domino hotel invites guests to have a drink at a swim-up bar. The bar area includes a sun terrace. Serving European meals, La Fenice lies around a 5-minute drive from the Kyrie Isole Tremiti.