Located 1.5 km from the Monument to Italian Sailors, Largo Otranto - Guest House Brindisi is a 6-minute walk from the Archaeological Site of Saint Peter of the Slavs. The hotel also includes parking.

This comfortable guest house provides a prime location in close proximity to the 16th-century Renaissance-style palace "Palazzo Granafei Nervegna". The Church of Santa Maria del Casale is 2.2 km from the Largo Otranto - Guest House, while Banchina Stazione Marittima bus stop is about 600 metres away. The Castello Svevo di Brindisi is within a few blocks of the property. For those travelling from afar, Casale airport is 10 minutes' drive away.

The air-conditioned rooms have a sitting area and a living room featuring wireless internet and a flat-screen TV with satellite channels, along with comforts such as an air conditioner and soundproof walls. In addition, there are an electric kettle and a fridge for self-catering purposes. Bathrooms, equipped with a bidet, a separate toilet, and a shower, also feature shower caps and towels.

The 4-star Largo Otranto - Guest House is in the immediate vicinity of the seafood restaurant Sushiro.