Located approximately a 5-minute walk from Chiesa del Preziosissimo Sangue in San Rocco, the 4-star smoke-free Domus Nikolai Hotel Bari gives quick access to various city sites. Guests will appreciate the views of the city and a prime location near a train station, while staying in the comfortable guest house.

The Italian University of Bari is merely 1 km away, and the sand San Francesco All'Arena Beach is 3.1 km from the hotel. The entertainment attractions in the Municipio 1 district of Bari include the Margherita Theatre, which is around 25 minutes' walk away. Also, Giardini di Piazza "Umberto Primo" is situated 800 metres away. The Domus Nikolai Bari is within reach of the Petruzzelli Theatre. The property is about a 5-minute ride from Piazza Moro bus station.

The soundproofed rooms provide a mini fridge bar, tea and coffee making equipment, along with a flat-screen TV with satellite channels for guests' comfort. There are separate bedrooms and private bathrooms with a bidet, a separate toilet, and a shower provided. Featuring a bidet, a separate toilet, and a shower, the bathrooms also have a hairdryer and bathrobes.

Enigma Cafe' is located next to Domus Nikolai Hotel and serves Italian dishes, right around the corner from the property.