Located 800 metres from the Sant'Oronzo Square, Palazzo Guido Bed & Breakfast Lecce includes 6 rooms with views of the city. The bed & breakfast is within reach of Porta Rudiae and provides guests with a Jacuzzi and a sauna.

This 4-star hotel is steps from an underground station and 0.7 km from the Public Gardens. The Palazzo Guido Bed & Breakfast also gives access to the Must Museum, which is about 850 metres away. Options for cultural tourism include the Colonna di Sant'Oronzo, situated 0.8 km away. City Terminal bus station is only a few steps from this accommodation.

An air conditioner, along with a minibar fridge, coffee and tea making equipment, provide in-room convenience at the boutique-style hotel. Bathrooms with a bidet, a separate toilet, and a shower, also feature hair dryers and bath sheets for guests' extra comfort.

Palazzo Guido Bed & Breakfast offers a buffet breakfast daily. Gastronomic options include a lounge bar. The sushi bar Fusion Restaurant lies 5 minutes' walk from this property.