Located 3.1 km from the sand San Francesco All'Arena Beach, Casa Mela Bed & Breakfast Bari is a mere 5 minutes' walk from the 13th-century Romanesque church "Bari Cathedral". There is also a car park.

The bed & breakfast has a prime location in the vicinity of the public Pinacoteca metropolitana di Bari Gallery. The Pontifical Basilica San Nicola is merely 450 metres from the Casa Mela Bed & Breakfast Bari, and the Lungomare Araldo Di Crollalanza is around 1 km away. The nearby cultural attractions include the Petruzzelli Theatre, which is in proximity to this 3-star hotel. The property is also within 15 minutes' walk of Bari Central train station.

The rooms at this hotel are fitted with tile floors and such comforts as climate control. There is also a private bathroom.

The seafood restaurant La Tana del Polpo lies in close proximity to Casa Mela Bed & Breakfast.