Located merely 1.1 km from the 17th-century baroque church "Basilica of Santa Croce", the 4-star B&B Ai Due Santi Lecce is a mere 6 minutes' walk from the Porta San Biagio.

The bed & breakfast is about 50 km from Casale airport and within a few blocks of such cultural venues as the Colonna di Sant'Oronzo. This Lecce hotel gives access to the Church of Saint Irene, which is only 13 minutes' walk away. There is the Parco di Belloluogo within a 2-km distance of the B&B Ai Due Santi Lecce. The accommodation is approximately 5 minutes' drive from Via di Leuca bus stop and within reach of Lecce train station in Lecce.

The rooms comprise a balcony and a sitting area complete with air conditioning, as well as a flat-screen TV with satellite channels. They are appointed with a writing desk, and also feature a mini-fridge-bar, coffee and tea makers. A bidet, a separate toilet, and a shower, along with hair dryers and a shower cap, are provided.

B&B Ai Due Santi features a daily Italian breakfast. The bakery Pasticceria Durante is located only a few steps from the hotel.