Located fairly close to the Obelisk of Sant'Oronzo, Dimora Guarini Villa Ostuni offers quick access to various city attractions in the vicinity.

The Parish Sanctuary of Saints Cosma and Damiano is about 700 metres from the Ostuni villa, while guests can also visit the Museum of Preclassical Civilizations of Southern Murgia Hills, which is only a 5-minute walk away. The property is not far from places of worship such as the Church of Santa Maria degli Angeli. Dimora Guarini Villa is 2.2 km from the Cavalcata di Sant'Oronzo.

Osteria Ricanatti is a restaurant serving contemporary dishes right near the Ostuni accommodation. Transportation alternatives in the area include Corso Vittorio Emanuele bus stop, located a mere 5 minutes' stroll away.